In previous studies, the sum concentrations of clozapine and its metabolite, norclozapine, and the norclozapine to clozapine ratio were also used as a clinical outcome and an index of metabolic activity, respectively.1 However, we could not use these parameters for the present meta-analysis, because we used only the clozapine C/D ratio in order to be able to include as many studies as possible and to develop simple standards that can be used in clinical practice
Using a conservative effect size of 0.2, for an error of 5% and a power of 80%, a minimum of 199 subjects would be required
Ministry of Health and Family
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